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Rosalie M. Luiten PhD

Logo SNIPDepartment of Dermatology and
The Netherlands Institute for Pigment Disorders
Academic Medical Center
University of Amsterdam
Meibergdreef 9, room L3-116
NL-1105 AZ Amsterdam
The Netherlands

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Research experience:

2008 to present: Head of the Laboratory of Experimental Dermatology
2007 to present: AMC principal investigator (PI)
2005-present: Assistant professor at the Netherlands Institute for Pigment Disorders and department of Dermatology of the Academic Medical Center of the University of Amsterdam. Studying the pathogenesis of vitiligo and its application in immunotherapy of melanoma. Supervisor of two PhD students, one Postdoctoral fellow, two technicians and one MSc student.

Awarded in 2005 a research grant of €460,000 from the Dutch Cancer Society to study the susceptibility of melanoma for autoimmune attack, an important prognostic factor for the potential success of immunotherapy in combating melanoma.

2003-2004
Senior Postdoctoral Research Fellow at the Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden. Awarded a research grant (€ 110,000) from the Netherlands Institute of Pigment Disorders at the University of Amsterdam to start a new research line on the pathogenesis of vitiligo and its application in immunotherapy of melanoma.

In 2004, awarded the NWO-VIDI personal grant of € 600.000 from the Innovational Research Program of the Dutch Organization of Scientific Research (NWO).

1999-2003
Postdoctoral Research Fellow at the Department of Immunology, The Netherlands Cancer Institute / Antoni van Leeuwenhoek hospital, Amsterdam. Developed innovative immunotherapeutic strategies, including autologous tumor cell vaccines and immortalized human T lymphocytes, for the treatment of melanoma. Treatment evaluation performed both in experimental models and in melanoma patients in a Phase I clinical study.

1997-1999
Marie Curie Research Fellow at the Ludwig Institute for Cancer Research (LICR) in Brussels (dr. P. van der Bruggen, Prof. dr. T. Boon).
Marie Curie postdoctoral research fellow at the Christian de Duve Institute of Cellular Pathology, Cellular Genetics Unit, in Brussels. Awarded a personal fellowship (€ 150,000) to work two years in the group of dr. P. van der Bruggen and prof. dr. T. Boon. Developed cancer vaccines derived from MAGE genes. Invented five new cancer vaccines that are patented worldwide for clinical application.

Research fellowships:

2008 KWF fellowship for medical interns granted to drs. H-E Teulings
2007 Dutch Cancer Society (KWF) Research grant in collaboration with dr. K.A. Reedquist, Dept of exp Immunology, AMC.
2005 Dutch Cancer Society (KWF) Research grant
2004 NWO (Netherlands Organization of Scientific Research) -VIDI research fellowship
2003 The Netherlands Institute of Pigment Disorders (SNIP) research fellowship
1997 Marie Curie Individual Research fellowship from the European Commission (TMR).
1993 Research fellowship from Centocor Inc. (Malvern, PA)

Teaching experience:

2007 Keuzeonderwijs in the AMC medical curriculum "Curius" for medical students.
2006-2007: Teaching high school students about the world of science.
2005 to present: teaching medical students about diagnostic techniques in dermatology.
2005 University of Amsterdam. Immunology course for Dermatologists (Munster, Germany).
Research workshops, called "profielwerkstukken", about the world of science for high school students.
2004 University of Leiden. Introduction course for first year students Biomedical Sciences.
2002 Schering Plough, Dardilly, France. Teaching of the retroviral transduction technique.
1993-2005
Supervision of multiple undergraduate students in research training projects throughout the research career.

Invited Lectures:

2008 Leiden Institute for Immunology, Leiden University Medical Center (Leiden, NL)
2008 Annual meeting of the Dutch Society for Experimental Dermatology (Lunteren, NL)
2007: Principal Investigator (PI) retreat of the Center for Immunology Amsterdam (CIA, Schoorl, NL).
2007: annual meeting of the PanAmerican Society for Pigment Cell Research (PASPCR, Chicago, IL).
2007: Van 't Hoff Institute for Molecular Sciences (HIMS) of the University of Amsterdam (Amsterdam,NL).
2007: KP7 congres 2007, the conference for the 7th Framework Program organised by EG Liaison (The Hague, NL)
2006: 13th meeting of the European Society for Pigment Cell Research 2006 (ESPCR06, Barcelona, Spain)
2006 Annual meeting of the Dutch Society for Experimental Dermatology (Lunteren, NL)
2005 International Pigment Cell Conference: A focus on human pigmentary diseases (plenary lecture, Washington, DC);
2002 American Association for Cancer Research special conference: The Role of Telomeres and Telomerase in Cancer (San Francisco, CA)
2001 The Netherlands Association for Gene Therapy conference (Nijmegen, NL)
2001 Staff symposium Immunology at the Netherlands Cancer Institute (Amsterdam, NL)
2001 ImAginE, Immunology and Ageing in Europe. 2nd conference on Basic Biology and Clinical Impact of Immunosenescence. (Cordoba, Spain)
1998 Pierre and Marie Curie Seminars, Institute Pasteur (Lille, France)
1995 International Society for Oncodevelopmental Biology and Medicine (ISOBM, Montreal, Canada)

Education:

1993-1997
PhD. at the University of Leiden.
Title of the thesis: "New chimeric monoclonal antibodies against human carcinoma. IgE and bispecific antibody-mediated therapy", (Prof. dr. S.O. Warnaar and Prof. dr. G.J. Fleuren); Prof. dr. L.J. Old, Ludwig Institute for Cancer Research, New York, USA (referee).

1987-1993
Doctorandus (MSc.) in Biomedical Sciences, University of Leiden.
Performed 4 research projects in Immunohematology, Human genetics, Clinical Oncology, and Pathology.
Title of research thesis: "The 17-1A antigen as a target for immunotherapy of carcinomas".

Extra-curricular training period at the biomedical company Centocor Inc. in Malvern, PA, USA, based on outstanding research performance. Title of thesis: "Generation of chimeric bispecific monoclonal antibodies for clinical application in renal cell carcinoma patients."

Certificates of extra-curricular exams in Italian Language, University of Leiden.

1986-1987
First and second degree French Language and Literature at the University of Grenoble III, France.

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